A recent study showed that SIRT6 overexpression enabled mitochondria to maintain their functions and protect myocardial cells from DCM development by downregulating the expression of the negative Nrf2 regulator Kelch-like ECH-associated protein 1 (Keap1), which stabilized Nrf2 [128]. This evidence concerns the gene NFE2L2 and familial dilated cardiomyopathy.