A variety of growth factors, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 fibroblast growth factor (FGF), transforming growth factor (TGF)-α, TGF-β, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF-1), have been identified to enhance neurogenesis and angiogenesis in response to stroke [107]. This evidence concerns the gene IGF1 and stroke disorder.