Shengqiong D et al. [24] showed that adipose-derived MSCs (ADMSC) exosomes promoted the polarization of M2 macrophage, while the suppressive effects of ADMSC exosomes on myocardial apoptosis and fibrosis induced by MI were reversed by sphingosine-1-phosphate receptor 1 (S1PR1). The gene discussed is S1PR1; the disease is myocardial infarction.