AKT1 and myocardial infarction: In addition, HucMSCs-exoTIMP2 pretreatment increased Akt phosphorylation level in infarcted myocardium, suggesting that HucMSCs-exoTIMP2 alleviates MI-induced oxidative stress and ECM remodeling, improving cardiac function partly through the Akt/Sfrp2 pathway.