,15,16,17,18,19,20,21 The components of this PDZD8 complex are associated with various neurological disorders,15,22,23,24,25,26 with mutation of PDZD8 itself being a risk factor for human intellectual disability including cognitive impairment27 and for posttraumatic stress disorder.28 This evidence concerns the gene PDZD8 and post-traumatic stress disorder.