Specific accumulation of CEs has also been detected in induced pluripotent stem cell-derived neurons from individuals with Alzheimer’s disease, in Trem2- or ApoE-deficient glia, and in the brain of individuals with Huntington’s disease3,5,53 Furthermore, the accumulation of CEs in Trem2-or ApoE-deficient glial cells was enhanced by clozapine, a selective inhibitor of the mesolimbic dopaminergic system.4 This evidence concerns the gene TREM2 and Alzheimer disease.