Microglia can upregulate recombinant sodium/hydrogen exchanger 1(NHE1) levels via colony‐stimulating factor 1(CSF‐1),52 release TGF‐β to trigger glioma cell production of precursor metalloproteinase 2 (pro‐MMP2), which is cleaved into active MMP2. This evidence concerns the gene SLC9A1 and central nervous system cancer.