DC maturation is stimulated by further cocktail therapy to induce high expression of MHCs and positive costimulatory molecules (e.g., CD80/86), promote the secretion of inflammatory cytokines (e.g., IL‐12, TNF‐α) and chemokines (e.g., CXCL9/10),71 and ultimately enhance the immune response mediated by T cells and immune cells migrate to the tumor site, thus improving the tumor microenvironment72 (Figure 4). This evidence concerns the gene TNF and neoplasm.