A study showed that intra tumoral (IT) injection of antigen‐pulse DC cells improves the TME by reducing TGF‐β,87 increasing TNF‐α and IFN‐γ, promoting proliferations of CD8+ T cells, reducing Tregs activation, and increasing the survival rate of mice with glioma.88 The gene discussed is TGFB1; the disease is central nervous system cancer.