The elevated lactate not only activates the G protein‐coupled receptor GPR81 on DCs, which promotes the growth of tumor cells and thus inhibiting MHCs on DCs,66 but also inhibits the release of IFN‐α and IFN‐γ from pDCs through this receptor, and weakening the anti‐tumor immunity caused by DCs.67 The gene discussed is IFNG; the disease is neoplasm.