Some studies have shown that it can be used to prevent and counteract the symptoms of COVID-19.433,434 An in -silico study also revealed that it can interact with SARS-CoV-2 proteins (Mpro, RdRp, NSP15, and S protein).435 In addition, the three main forms of vitamin A, retinol, retinal, and tretinoin, are also carotenoids with potential anti-COVID-19 effects. This evidence concerns the gene PROS1 and COVID-19.