According to a study by Wang et al., Sal-A dose-dependently alleviates the pathological alterations in mice with acute lung inflammation due to infection with SARS-CoV-2 S protein-pseudotyped virus in a dose-dependent manner.378 Sal-C has been reported to potently bind to the 6-HB core of S protein, thereby inhibiting SARS-CoV-2 infection.379 According to the in vitro results, Sal-C potently inhibits the membrane fusion of S protein–overexpressing HEK293T and Vero E6 cells with an IC50 of 1.71 μM. Here, PROS1 is linked to infection.