With the development of molecular biology, tumor biomarkers are of great clinical value for screening malignant tumors, such as cancer embryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin fragment antigen21-1 (CYFRA21-1), and squamous cell carcinoma-related antigens, which are widely used in clinical practice [8]. Here, ENO2 is linked to squamous cell carcinoma.