With extensive studies, an increasing number of molecular mechanisms that promote HCC are being discovered, including the inactivation of tumor suppressor genes (such as p53), abnormal activation of oncogenes (such as K-ras), multiple signaling pathways (PI3K, MAPK, JAK/STAT, etc.), and abnormal regulation of epigenetic factors (such as microRNAs) are all involved in HCC development and progression [5]. The gene discussed is TP53; the disease is hepatocellular carcinoma.