Further analysis of the relationships between CD97-co-expressed genes and TIICs in HCC showed that IQGAP1, GMIP, MOBKL2A, ARPC2, CD68, and FAM102B were significantly positively correlated with TIICs, especially macrophages (all r ≥ 0.281, P < 0.001; Fig. 5b–g). The gene discussed is IQGAP1; the disease is hepatocellular carcinoma.