It has been reported that the basal level expression of MR1 on a variety of tumor cell lines is low to undetectable; however, upon exposure to microbial metabolites 5-OP-RU, B16F10 melanoma cells significantly upregulated MR1 surface expression in a dose-dependent manner, but not for RIL-175 or CT269. The gene discussed is MR1; the disease is melanoma.