While the oncolytic effect might be due to collective effect of the oncolytic proteins, many (48/147) of the top unique pathways (different from those of the oncogenic significant proteins with p value < 0.05) of the significant proteins involve PIK3R1 (see Table S6 for unique pathways and proteins involved): e.g., CD28 dependent PI3K/Akt signaling, Signaling by cytosolic FGFR1 fusion mutants, Signaling by PDGFR in disease, etc. PIK3R1 is a known tumor suppressor75. This evidence concerns the gene CD28 and neoplasm.