3a) along with literature supports are given in Table S5.2. For 10 of the 12 proteins, we have literature evidence of their associations with cancers. For example, MIN, NUP214, PABPC1, LARP4B & DDX10 are established cancer drivers in the COSMIC database67. The top protein, MIN, is associated with the risk of colorectal cancer71. Knockdown of the second protein MOV10 leads to upregulation of INK4, a tumor suppressor72. Inhibition of the third protein NUP214 leads to cell death73. PABPC4 plays role in the pathogenesis of colorectal cancer74. The gene discussed is DDX10; the disease is cancer.