These results showed the lowest expression of osteopontin in the early acute phase up to 4 h post stroke and the highest expression in the late acute phase of 15 h post stroke, after which the expression saturated until 24 h, the endpoint of our murine ischemic stroke model of tMCAO (Fig. 1, Supplementary Fig. S1). The gene discussed is SPP1; the disease is ischemic stroke.