PTGS1 and coronary artery disorder: In particular, the beneficial role of antiplatelet therapy in coronary artery disease has been well-established with ADP antagonists (clopidogrel, ticagrelor, and prasugrel inhibiting the P2Y12 receptor) and aspirin (acetylsalicylic acid)-inhibiting TXA2 synthesis through cyclo-oxygenase-1 (COX-1) blockade, which are used as dual or single therapy depending on clinical conditions.