Excluding RUNX1 mutated cases from WHO MDS-SF3B1 led to a more significant separation regarding OS between MDS-SF3B1 cases and non-MDS-SF3B1 cases with LB (p = 0.003 vs. p = 0.038; Supplementary Fig. S4G/E). The gene discussed is SF3B1; the disease is myelodysplastic syndrome.