The common hub RP11-445H22 has the most immune cooperative partners and could regulate CRTAM, CADM1, CXCR3, CXCL10, PDCD1, and CD274 to mediate tumor-T cell interactions as shown in Fig. 3f, which plays a role in promoting tumors and suppressing immunity. The gene discussed is PDCD1; the disease is neoplasm.