LINC00324 is a specific hub in SKCM, and could be involved in tumor cell-NK cell interactions by regulating TNFSF18, TNFRSF18, CRTAM, and CADM1. Furthermore, these three hubs IC-lncRNAs could co-regulate various immune functions with 363, 220, and 50 partners respectively, such as lymphocyte activation, inflammatory response, and interleukin biosynthetic (Fig. 3g). This evidence concerns the gene TNFRSF18 and neoplasm.