Interestingly, the combination of UTMD and doxorubicin (Dox) was able to induce the translocation of calreticulin (CRT) and ER-associated protein disulfide isomerase ERp57 and upregulate the expression of chromatin-binding protein high-mobility group B1 (HMGB-1) in tumour cells, suggesting the activation of ICD. This evidence concerns the gene HMGB1 and neoplasm.