HHIP and malignant colon neoplasm: Gene profiling of single cells revealed that RGS5-expressing myofibroblasts, CXCL14-expressing fibroblasts and HHIP+ myofibroblasts showed extensive upregulation of extracellular matrix genes, including collagen genes, in colon cancer tissues (Fig. 4c, d, Supplementary Fig. 2a, b, Supplementary Data 5).