Consistent with this, the transcriptomic profile of trisomic NPCs showed a decrease in EZH2 and EED mRNA, as well as some histone acetyltransferases, further supporting the proposed diminished activity of PRC2 in DS, possibly due to increased dosage of HMGN1. Remarkably, transcriptional profiling of trisomic NPCs revealed senescence-associated signatures as well as upregulation of genes related to cell migration, adhesion, and inflammation. The gene discussed is HMGN1; the disease is Dravet syndrome.