HMGN1 and Dravet syndrome: The HMGN1 mRNA was found to be increased in the cortex, hippocampus, and cerebellum of the Ts1Cje mice [194, 195], representing another mouse model of DS that contains a partial triplication of Mmu16 [196], and in the embryonic brain tissue of Ts65Dn [197], the most widely used mouse model of DS, containing an extra-small chromosome resulting from a fusion of the region of Mmu16 orthologous to Hsa21 with the centromeric region of Mmu17 as well as the additional extra segment of non-DS-related genes [198].