On the other end of the spectrum, several decreased curvature pathways have been implicated with tumor-suppressor involvement in melanoma and, such as PAK degradation, where PAK is a known driver of drug resistance in melanoma, and several other tumor-suppressive pathways including p53 and DNA damage response pathways (which were also significantly enriched but not shown in top 10, see Supplementary Table S2)61,62. This evidence concerns the gene TP53 and neoplasm.