POMT1 and Abnormality of neuronal migration: For example, POMT1 (protein O-mannosyltransferase) mutation disrupts the glycosylation of laminin binding site on DAG1, leading to Walker-Warburg syndrome—a severe neuronal migration disorder, in which patients exhibit severe muscular dystrophy, brain malformations, abnormal eye development, and BBB impairment [51, 52].