LAMB2 and congenital muscular dystrophy due to LMNA mutation: It has been reported that laminin-α2 null mice, a mouse model of congenital muscular dystrophy, develop BBB impairment [57]; loss of astrocytic laminin leads to severe BBB disruption and spontaneous intracerebral hemorrhage [58]; and ablation of laminin-γ1 in PDGFRβ+ cells leads to muscular dystrophy and BBB breakdown in the C57Bl6/FVB mixed background [16, 59].