ANXA5 and cancer: We recognized an induction in total apoptosis (early and late apoptotic cells), Annexin V-positive/PI-negative as Annexin+/P.I, and the lowest percentage of necrosis (Annexin-/PI+) in cured cells while at the end-stage of apoptotic cells are Annexin V/PI++ showed as Annexin V-FITC positive/PI-positive, compared with the control group in all four targeted cancer cell lines.