ITGAE and neoplasm: Flt3L-expressing FOLactis can directly expand the local proliferation and differentiation of a specialized cross-presenting DC subset, conventional-type-1-dendritic cells (cDC1) especially CD103+ CD11c+ and CD8α+ CD11c+ dendritic cells, which are professional at taking up dead tumor cells, transporting tumor-specific antigens, promoting endogenous antitumour T cell epitope spreading23 and re-stimulating tumor-specific CD8+ T cells24.