TGFB1 and neoplasm: In the TME, tumour-associated macrophages, neutrophils and myeloid-derived suppressor cells (MDSCs) and cytokines such as IL-6, IL-10, and TGF-β can participate in the formation of an immunosuppressive microenvironment by altering and modifying systems with high plasticity components, leading to immune escape of tumour cells and promoting tumour progression [24].