Furthermore, scatter plot analyses showed significant positive correlations of SET/CIP2A expression with the expression levels of the IEGs (TRIB1, SPRY4, CTGF) and with those of growth-promoting genes (cyclin D1, E2, and PCNA) in KRAS-mutated pancreatic cancers (Fig. 8d, e). Here, SPRY4 is linked to familial pancreatic carcinoma.