SETD2 and colitis: Nevertheless, when transferred together with CD45RBhigh pathogenic T cells into Rag2–/– mice, splenic Setd2-deficient Treg cells had a reduced capacity to suppress colitis compared to control Treg cells in vivo (Fig. 3a, b), as indicated by the greater body weight loss and shortened colons of recipient mice (Fig. 3b–d).