Besides, the conjugate showed a high antitumor effect in SGC-7901 tumor model with a tumor inhibition rate of 59.57%, and which might be mediated by increasing the levles of TNF-α, Bax and Caspase-3 and reducing the levels of CD34, VEGF, MMP-2, MMP-9 and Bcl-2 [101]. The gene discussed is MMP2; the disease is neoplasm.