Compared with Lac-NCTD and Lac-NCTD CS NPs (Lac-NCTD-CS-NPs), Lac-NCTD-TMC-NPs had the strongest antitumor effect both on the HepG2 cell and the murine hepatocarcinoma 22 tumor models, indicating that the recognition of ASGPR located on the surface of hepatoma cells can enhance the liver targeting ability. The gene discussed is ASGR1; the disease is neoplasm.