CACNA1I and schizophrenia: Spindle deficits in healthy first-degree relatives [56] and genetic studies showing an association of the gene CACNA1I (that encode for the subunit CaV3.3 channel) with schizophrenia [57, 58], also support the hypothesis of a genetic risk factor involved in the thalamo-cortical system deficiency at the basis of spindle alteration.