The findings demonstrated that, as the development of T2DM, IL-17 + T cells gradually migrated from the periphery of pancreas islet to the center of the islet; while Th17 cells maintained to infiltrate surrounding the islet in exenatide-treated mice (Fig. 3C), disclosing that exenatide treatment could change the distribution rather than the proportion of IL-17 + T cells in pancreas. The gene discussed is IL17A; the disease is type 2 diabetes mellitus.