Along with the progression of diabetes, we found that the proportion of CD4 + IL-17 + Th17 cells was increased from 0.99 ± 0.07% to 2.46 ± 0.30% after 8-week treatment (P = 0.001, Fig. 2A, B) while CD4 + CD25 + Foxp3 + Treg cells were markedly decreased (Control 8 Week, 0.08 ± 0.01% vs Control 0 Week, 0.19 ± 0.04%, P = 0.037, Fig. 2C, D). Here, FOXP3 is linked to diabetes mellitus.