As Fig. 4D displayed, compared to cluster C1, the C2 subtype mainly enriched in KEGG pathways like Cell cycle, Homologous recombination, DNA replication, cancer-associated (like Bladder, Pancreatic, and Renal cell carcinomas) pathways, and signaling transduction axis including NOD-like receptor and mTOR signaling pathways, implying that cluster C2 might own a close association with the occurrence and evolution of HCC. This evidence concerns the gene MTOR and hereditary clear cell renal cell carcinoma.