PRKCD and hepatocellular carcinoma: In summary, these results preliminarily proved that our risk gene PRKCD could either participate in the modulation of malignant biological behaviors of cancer cells as well as regulate the activation of platelets in vitro, implicating that PRKCD might act as a key molecular bridge in the cross-talk between HCC cells and platelets and also take an essential part in the platelet-induced HCC progression.