Here, using models both in vitro and in vivo, we have corroborated that SKA1 is functional as an oncogenic molecule in ccRCC and have, for the first time, demonstrated that SKA1 can act as a co-regulator to induce the transcriptional repression of dual-specificity phosphatase 6 (DUSP6), facilitating EMT and tumor metastasis in ccRCC. Here, SKA1 is linked to neoplasm.