,45BAP1 is a tumor suppressor gene that has epigenetic functions in cancer46; however, co-occurring alterations in BAP1 are not prognostic for overall survival, objective response rate, or progression-free survival in patients with cholangiocarcinoma treated with pemigatinib, the selective FGFR1/2/3 inhibitor.19 This evidence concerns the gene FGFR1 and cholangiocarcinoma.