CFTR and myocardial infarction: Indeed, lumacaftor/ivacaftor combination therapy (3 mg/kg/1.875 mg/kg daily for 2 weeks, starting at 10 weeks post-myocardial infarction) normalises (i) hippocampal neuron CFTR expression (Fig. 5e, p < 0.001; ANOVA + Tukey's), (ii) hippocampal neuron dendrite length (Fig. 5f, p = 0.029; Kruskal–Wallis + Dunn's) and spine density (Fig. 5g, p < 0.001; ANOVA + Tukey's), and (iii) long-term memory, as measured by novel object recognition (Fig. 5h, p = 0.003; ANOVA + Tukey's) in mice at 12 weeks post–MI.