However, consistent with great heterogeneity in PCa and our model that PME‐1‐mediated phosphoproteome regulation can control different anoikis sensitivity mechanisms, we did not see evidence for increased histone 3 trimethylation in DU‐145 cells upon PME‐1 depletion on soft substrate (data not shown). Here, PPME1 is linked to posterior cortical atrophy.