PME‐1 inhibits PP2A activity both by directly binding to catalytic centre of the catalytic subunit PP2A‐C, and by regulating the methylation of the C‐terminal leucine 307 on PP2A‐C and thereby inhibiting recruitment of tumour suppressive B‐subunits to the PP2A complex [10, 13, 14]. Here, PPP2CA is linked to neoplasm.