We confirmed that nuclear lamins are increasingly dephosphorylated (detected with Lamin‐A/C phospho‐antibody) upon PME‐1 depletion (Fig. S4D,E) and that this effect is dependent on the PP2A complex B‐subunit PPP2R2A (Fig. S4D,E), an established tumour suppressor in PCa [6, 8]. Here, PPME1 is linked to posterior cortical atrophy.