EML4 and neoplasm: A high concordance between 5-mC scores and chromosomal instability (t-MAD score; Spearman, ρ = 0.609) as well as 5-mC scores and EML4-ALK fusion abundances (Spearman, ρ = 0.705) was observed, suggesting that cfMeDIP-seq profiles can inform about the abundance of tumor-derived cfDNA molecules in plasma samples (Fig. 1E).