In contrast, the protein expression levels of β-catenin, TCF4, Cyclin D1 and c-Myc in the ALV-J tumors were significantly higher than those in the tumor-adjacent and normal tissues, suggesting that the high expression of chTERT in tumors was positively correlated with the activity of the Wnt/β-catenin signaling pathway. The gene discussed is CCND1; the disease is neoplasm.