Since Western blot analysis showed that METTL4 and lncRNA RP11-390F4.3 overexpression activated the same set of EMT regulators (Fig. 2c, 4f) and lncRNA RP11-390F4.3 contains 6mA depositions on its promoter, we further characterized lncRNA RP11-390F4.3. To identify the localization of lncRNA RP11-390F4.3, we performed single-molecule RNA-FISH detection of lncRNA RP11-390F4.3 in tumor cell lines. This evidence concerns the gene METTL4 and neoplasm.