METTL4 and neoplasm: Due to the regulation of the same set of “core” EMT regulators by METTL4 and lncRNA RP11-390F4.3 (Fig. 2c, 4f) [41], the HIF-1α-METTL4-RP11-390F4.3 axis plays a crucial role in hypoxia-induced tumor progression.