To further confirm the above results, knockdown of METTL4 in a lung cancer H1299 cell line constitutively overexpressing HIF-1α [38] showed the reversion of EMT, a decrease in the expression of EMT regulators, and a decrease in the in vitro migration and invasion activity (Additional file 1: Fig. S2h, i). The gene discussed is METTL4; the disease is lung cancer.