SLC22A3 and acute myeloid leukemia: To investigate the clinical correlation of SLC22A3 methylation in pathogenesis and prognosis of MDS/AML, patients were divided into two distinct groups (SLC22A3 hypermethylation and SLC22A3 hypomethylation) based on the cutoff value of 0.042 (according to Youden index of ROC curve), which can also put almost all healthy donors in hypomethylation set.