Similarly, Anwar et al. [37] reported an association of survival of hepatocellular carcinoma patients with increased methylation of several of the same imprinted genes and imprinted gene regions (GNAS at 20q13.32, the DLK1-DIO3 cluster at 14q32.2-q32.31, and ZIM3 at 19q13.43) in primary tumor samples, which were also associated with increased drug sensitivity in our pancancer analysis of tumor cell lines (Additional file 9: Table S6). This evidence concerns the gene DIO3 and hepatocellular carcinoma.