In contrast, 283 cell lines, or 45.4% of all cell lines, carried more than 2 copies of GNAS. The highest number of amplifications (5-9) was observed in pancreatic adenocarcinoma (HS766T), breast cancer (EFM19, AU565, HCC1954, HCC1428, MCF7, HCC1419, and UACC893), NSCLC (CHAGOK1), and colorectal cancer (SNU61 and HT55) cell lines. The gene discussed is GNAS; the disease is breast cancer.