Interestingly, higher copy number of the imprinted genes L3MBTL1 and SGK2 at 20q13.12 was weakly associated with drug resistance (Additional file 7: Table S4), and their increased expression was associated with resistance to several agents in leukemia tumor samples from the Beat AML study (Additional file 11: Table S8, Additional file 12: Fig. S4). This evidence concerns the gene L3MBTL1 and leukemia.