The three non-imprinted genes at 20q11-q13.32 examined in our study, AURKA, MYBL2, and ZNF217, have a strong influence on cell cycle, proliferation, signaling, survival, and differentiation of malignant cells and on cancer progression, and they have been implicated in cancer drug resistance [136, 137, 163–166]. The gene discussed is MYBL2; the disease is cancer.