Only the directions of associations with lenalidomide were mixed, including a positive correlation with ZNF217 expression and negative correlations with expression of GNAS and SGK2. The three strongest associations with drug resistance in the Beat AML dataset involved correlations of SGK2 and L3MBTL1 expression with resistance to nilotinib and of NNAT expression with resistance to TG101348 (0.3005 ≤ ρ ≤ 0.3343, 2.40 × 10–9 ≤ p0 ≤ 0.0058, 2.80 × 10–7 ≤ pFDR ≤ 0.0451; Additional file 11:Table S8). The gene discussed is GNAS; the disease is acute myeloid leukemia.