GNAS and colorectal cancer: In contrast, 283 cell lines, or 45.4% of all cell lines, carried more than 2 copies of GNAS. The highest number of amplifications (5-9) was observed in pancreatic adenocarcinoma (HS766T), breast cancer (EFM19, AU565, HCC1954, HCC1428, MCF7, HCC1419, and UACC893), NSCLC (CHAGOK1), and colorectal cancer (SNU61 and HT55) cell lines.