GNAS and leukemia: They included the imprinted genes SGK2, L3MBTL1, NNAT, and GNAS and the non-imprinted gene ZNF217. Similar to the CCLE-GDSC cell line dataset, the majority (8 out 10) of associations in AML cells satisfying Spearman |ρ|> 0.25 and pFDR < 0.1 were positive, indicating that increased gene expression in patient leukemia cells was associated with their resistance to nilotinib, TG101348 (fedratinib), lestaurtinib (CEP-701), and panobinostat.