p.Thr705Met is an unpublished variant that is predicted to be pathogenic by computational algorithms, p.Asn746His has previously been found in four probands initially suspected of having X-Linked Hypophosphatemia (XLH) but is considered a VUS by both our interpretation and interpretations in ClinVar, and p.Lys905AlafsTer16 and p.Tyr451Cys have been found in multiple patients with GACI/ARHR2 and are interpreted as Pathogenic and Likely Pathogenic, respectively [13–16]. Here, ENPP1 is linked to hypophosphatemia.