Furthermore, we evaluated the expression level of TGFBR3 in ESCC patients with different genotypes, and found that individuals carrying rs1804506 TT genotype had significantly decreased TGFBR3 expression in cancerous tissues than those carrying rs1804506 CC genotype (Fig. 3A). This evidence concerns the gene TGFBR3 and esophageal squamous cell carcinoma.