Moreover, our K-M survival analysis of children with ALL receiving chemotherapy-only showed that the 10-year predicted EFS rate was significantly lower in MLL-r positive cases receiving chemotherapy-only than in the negative group (54.32 ± 16.89% versus 76.78 ± 11.01%, P = 0.018) (Fig. 2A), and the 10-year predicted OS rate also tended to be lower in the positive group than in the negative group (72.19 ± 16.88% versus 84.84 ± 9.97%, P = 0.11) (Fig. 2B). This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.