The NLRP3 inflammasome plays a pivotal role in guiding host immune responses against bacterial, viral, and fungal infections [67]; however, its dysregulated activation was associated with the onset and progression of several age-related pro-inflammatory diseases, such as diabetes, atherosclerosis, gout, as well as neurodegenerative disorders, like Alzheimer’s disease and PD [65]. This evidence concerns the gene NLRP3 and Parkinson disease.