SNCA and Parkinson disease: Among them, a functional antibody capable of inhibiting TLR2 in PD mouse models substantially decreased aggregation and deposition of α-synuclein within neurons and microglia as well as neuroinflammation and neurodegeneration [82]; similarly, the small molecule CU-CPT22 inhibits the heterodimer TLR1/TLR2 and showed to have some neuroprotective and anti-inflammatory actions in cultured microglial cells [86].