SNCA and Parkinson disease: In any case, despite PD pathogenesis is yet largely unknown, there are at least two main hypotheses to explain the onset and progression of the disease: the first posits that misfolding and aggregation of alpha-synuclein (α-syn) are pathologically linked to death of dopaminergic neurons, while the second hypothesis proposes that the culprit is mitochondrial dysfunction and the consequent oxidative stress, including generation of toxic oxidized DA species [11, 12].