Interestingly, we found that HJURP was positively associated with dysfunctional T cells, but hypomethylation of HJURP was correlated with the shorter OS in different tumors including glioma, melanoma, renal clear cell carcinoma, renal papillary carcinoma, breast cancer and cholangiocarcinoma (Fig. 4B–H). This evidence concerns the gene HJURP and clear cell renal carcinoma.