HJURP and central nervous system cancer: Interestingly, we found that HJURP was positively associated with dysfunctional T cells, but hypomethylation of HJURP was correlated with the shorter OS in different tumors including glioma, melanoma, renal clear cell carcinoma, renal papillary carcinoma, breast cancer and cholangiocarcinoma (Fig. 4B–H).