BCL2 and intrahepatic cholangiocarcinoma: In ICC, “double-hit” HGBCL now comprises two entities: (1) HGBCL with MYC and BCL2 rearrangements (with or without BCL6 rearrangement) (HGBCL-DH-BCL2); and (2) a provisional entity named “HGBCL with MYC and BCL6 rearrangements (HGBCL-DH-BCL6)” (Table 1).