Xie et al., for example, developed a new biomimetic immunomagnet (IMS) to enrich circulating tumor cells (CTCs) using N3-modified leukocyte membranes.196 According to research, the lack of CTCs in blood makes it hard for efficient CTC enrichment or targeting.197 They used bioorthogonal reaction to attach epithelial cell adhesion molecule (EpCAM) to the surface of IMSs. Here, EPCAM is linked to neoplasm.