Zhang et al. used a bioorthogonal reaction to bind liposomes containing cholesterol esterase inhibitor Avasimibe (Ava) to the surface of T cells, enhancing the tumor-killing ability of T cells.108 High cholesterol concentrations in T cell membranes have been shown to trigger TCR aggregation and immunological synapse formation, boosting T cell tumor-killing ability.227 The authors first exploited the lipid insertion concept to introduce Tre-modified phospholipids into the surface of T cells. This evidence concerns the gene CEL and neoplasm.