TAFAZZIN and neoplasm: The presence of YAP/TAZ in TDO grown in Matrigel is likely due to the different stiffness of Matrigel compared with 3D-dECMs and the absence of factors previously released from the tumor cells, which are instead present in the 3D-dECMs and could regulate YAP/TAZ signaling activity (Panciera et al., 2017).