Bolus administration of insulin (12.5–25–50–100 μU) into the common carotid artery elicited significant hypoglycaemia (P = 0.0001; Table 1) and significant changes in arterial pH (P = 0.0457) and PCO2 (PaCO2;P = 0.0097; Table 1). Here, INS is linked to Hypoglycemia.