L1CAM and cancer: L1‐CAM is a transmembrane protein involved in the dynamic process of cancer metastasis and invasion of a secondary tumor site, and therefore, is often overexpressed in CRC.[26] Recent findings suggest that this antigen helps CRC cells adhere and spread on the surface of blood capillaries, initiating the metastatic outgrowth in perivascular sites.[27, 28] The specific interactions of antibody‐modified DNPs‐Gel with CRC cells expressing high levels of L1‐CAM would prevent off‐target effects caused by unspecific DNP uptake and galunisertib release.