Users of SGLT2i exhibited the lowest crude incidence rate of AKI (18.3 [CI 95% 14.1–23.4] per 1000 person-years), followed by GLP1-RA users (22.5 [CI 95% 19.9–25.3] per 1000 person-years) and DPP-4i users (26.6 [CI 95% 25–28.2] per 1000 person-years). The gene discussed is GLP1R; the disease is acute kidney injury.