The recent studies with hIgE mAb 2F10 and Der p 2 can be extended to other allergens to define the repertoire of IgE epitopes on these molecules and to answer a fundamental question that has eluded allergists for many years “What do IgE antibodies recognize and what constitutes an ‘allergenic’ epitope?” This is especially relevant for food allergens where there is increasing debate about the role of linear or conformational epitopes in the etiology of food allergy and in the development of tolerance to food allergens. Here, IGHE is linked to food allergy.