LPL and Schnyder corneal dystrophy: Decreased LPL activity in SCD may be due to increased levels of endogenous LPL inhibitors, e.g. angiopoietin-like proteins (ANGPTL)(Vendrame, Olops, Saad, Costa, Fertrin 2019), or transfusion iron overload(Kim, Jia, Buckett, Liu, Lee, Wessling-Resnick 2013).